AstraZeneca, Amgen’s asthma launch Tezspire picks up backing from England’s NICE

Title: AstraZeneca and Amgen’s Asthma Treatment Tezepelumab Receives Support from England’s NICE


A new chapter in the treatment of severe asthma has opened as AstraZeneca and Amgen’s innovative therapy, Tezepelumab, receives backing from the National Institute for Health and Care Excellence (NICE) in England. This pivotal decision marks an important milestone in the availability of targeted treatments for individuals suffering from severe forms of this chronic respiratory condition. In this blog post, we will explore the key points surrounding NICE’s support for Tezepelumab and its potential impact on the lives of asthma patients in the UK.

Key Points:

  1. Understanding Severe Asthma:
    Severe asthma is a complex and debilitating form of asthma that affects a small but significant subset of individuals. Traditional asthma medications often fail to sufficiently control the symptoms in these patients, leaving them at risk of frequent and severe asthma attacks, decreased lung function, and reduced quality of life.
  2. Tezepelumab: A Breakthrough Therapy:
    Tezepelumab is an innovative biologic medicine developed by AstraZeneca and Amgen that targets the root cause of severe asthma. It works by inhibiting the action of an immune system protein called thymic stromal lymphopoietin (TSLP), which plays a crucial role in the development and persistence of airway inflammation in asthma.
  3. NICE’s Backing:
    The National Institute for Health and Care Excellence (NICE) in England has recognized the potential of Tezepelumab and offered its support by issuing a positive guidance. This endorsement by NICE means that the therapy has met the necessary criteria for effectiveness and cost-effectiveness, paving the way for its use within the National Health Service (NHS) in England.
  4. Transforming Asthma Management:
    The support from NICE for Tezepelumab marks a significant turning point in the management of severe asthma. With the availability of this targeted therapy, healthcare providers can now offer a more effective and personalized treatment option to patients who previously had limited choices. Tezepelumab has the potential to reduce asthma exacerbations, improve lung function, and enhance patients’ overall quality of life.
  5. Addressing Unmet Medical Needs:
    The approval of Tezepelumab by NICE is particularly crucial as it fills an unmet medical need in the treatment landscape for severe asthma. For patients who have not responded adequately to existing therapies, this innovative biologic medicine offers renewed hope and a chance for improved symptom control and disease management.
  6. Advances in Precision Medicine:
    Tezepelumab’s approval exemplifies the progress being made in the field of precision medicine, where treatments are tailored to target the specific mechanisms relevant to a patient’s condition. By specifically targeting TSLP, Tezepelumab showcases the potential of precision therapies in improving patient outcomes and shaping the future of asthma care.


The support from England’s NICE for AstraZeneca and Amgen’s Tezepelumab represents a significant development in the treatment of severe asthma. With this innovative therapy, individuals suffering from severe forms of asthma now have access to a targeted treatment option that addresses the underlying causes of the disease. The approval of Tezepelumab underscores the commitment to advancing precision medicine and improving patient outcomes in the field of respiratory conditions. As Tezepelumab becomes available through the NHS in England, it brings renewed hope and improved quality of life to those living with severe asthma, setting an example for other countries and further driving progress in asthma treatment globally.